Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.47 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 4/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047655 | 0.85 | AKT1 (0.51) | AKT1HRH4DOT1LAKT2LRRK2 | |
| SCHEMBL9047322 | 0.77 | KIT (0.48) | AKT1HRH4HTTKITPDE10A | |
| SCHEMBL26646946 | 0.77 | PDE1B (0.40) | HTTLRRK2PDE10APDE3BPDE3A | |
| SCHEMBL30068291 | 0.77 | PDE1B (0.40) | HTTLRRK2PDE10APDE3BPDE3A | |
| SCHEMBL9048311 | 0.75 | AKT1 (0.47) | AKT1HRH4DOT1LAKT2LRRK2 | |
| SCHEMBL29243325 | 0.75 | KMT2A (0.46) | HTTLRRK2 | |
| SCHEMBL29243323 | 0.75 | KMT2A (0.46) | HTTLRRK2 | |
| SCHEMBL26647188 | 0.75 | KMT2A (0.46) | HTTLRRK2 | |
| SCHEMBL30068001 | 0.75 | KMT2A (0.46) | HTTLRRK2 | |
| SCHEMBL14275566 | 0.74 | AKT1 (0.52) | AKT1HRH4DOT1LAKT2MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714896-A1 | INDOL DERIVATIVES USEFUL FOR THE TREATMENT OF MIGRAINE, COMPOSITION AND UTILIZATION | VITA-INVEST, S.A. (ES) | 1996-06-05 | — | — | EP | disclosed |