Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetophenone SCHEMBL6684394 | 0.96 | LMNA (0.47) | LMNAMAPTSMN1; SMN2ALDH1A1MAOB | |
| Acetophenone SCHEMBL9387329 | 0.93 | CES2 (0.44) | LMNAMAPTSMN1; SMN2ALDH1A1MAOB | |
| Acetophenone SCHEMBL873136 | 0.86 | LMNA (0.39) | LMNAMAPTSMN1; SMN2ALDH1A1MAOB | |
| Benzil SCHEMBL1230822 | 0.84 | CES2 (0.50) | LMNAMAPTSMN1; SMN2ALDH1A1KMT2A | |
| Benzil SCHEMBL1923895 | 0.84 | CES2 (0.54) | LMNAMAPTSMN1; SMN2ALDH1A1KMT2A | |
| Ethylene SCHEMBL8144692 | 0.83 | LMNA (0.39) | LMNAMAPTALDH1A1KMT2AL3MBTL1 | |
| Ethylene SCHEMBL9049073 | 0.83 | LMNA (0.39) | LMNAMAPTSMN1; SMN2ALDH1A1MAOB | |
| Ethylene SCHEMBL10883680 | 0.83 | KMT2A (0.47) | LMNAMAPTSMN1; SMN2ALDH1A1KMT2A | |
| Ethylene SCHEMBL9411120 | 0.83 | MAOB (0.49) | LMNAMAPTALDH1A1MAOBKMT2A | |
| Ethylene SCHEMBL9411097 | 0.82 | KMT2A (0.46) | LMNAMAPTSMN1; SMN2ALDH1A1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555068-B1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1996-04-10 | — | — | EP | disclosed |
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0555068-A1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |