SCHEMBL9049262

SCHEMBL9049262

Cc1noc(C23CCN(CC2)C3)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.48
HSD11B1 P28845 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9048701 0.94 HSD11B1 (0.44) CHRM2HSD11B1
SCHEMBL9049643 0.90 HSD11B1 (0.46) CHRM2HSD11B1
Oxalic Acid SCHEMBL9051385 0.86 HSD11B1 (0.39) CHRM2HSD11B1
SCHEMBL8790855 0.83 HSD11B1 (0.46) CHRM2HSD11B1
Oxalic Acid SCHEMBL9050512 0.82 HSD11B1 (0.41) CHRM2HSD11B1
SCHEMBL22629097 0.72 HSD11B1 (0.44) CHRM2HSD11B1
SCHEMBL22628919 0.70 HSD11B1 (0.47) CHRM2HSD11B1
SCHEMBL9048913 0.70 TACR3 (0.32)
SCHEMBL22629101 0.69 HTT (0.44) CHRM2HSD11B1
SCHEMBL9049720 0.69 PDK2 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0287356-B1 Bridgehead substituted azabicyclic derivatives BEECHAM GROUP PLC (GB) 1996-01-24 EP claimed
US-5132316-A Cognition activators BEECHAM GROUP P.L.C. (GB) 1992-07-21 US claimed
EP-0287356-A2 Bridgehead substituted azabicyclic derivatives BEECHAM GROUP PLC (GB) 1988-10-19 EP claimed