Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 12/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047594 | 0.76 | ALOX5 (0.31) | ALOX5TSHR | |
| SCHEMBL8363012 | 0.73 | FBP1 (0.71) | FBP1PDK1HTR7 | |
| SCHEMBL7378002 | 0.70 | TSHR (0.37) | TSHR | |
| SCHEMBL9049842 | 0.70 | HPGD (0.56) | FBP1PDK1ALOX5 | |
| SCHEMBL5564912 | 0.70 | FBP1 (0.71) | FBP1PDK1HTR7TSHR | |
| SCHEMBL9049060 | 0.70 | ALOX5 (0.41) | ALOX5TSHR | |
| SCHEMBL10395762 | 0.69 | FBP1 (0.47) | FBP1PDK1HTR7TSHR | |
| SCHEMBL24742132 | 0.69 | SLC6A4 (0.39) | TSHR | |
| SCHEMBL2982080 | 0.69 | FBP1 (0.52) | FBP1PDK1HTR7 | |
| SCHEMBL9049175 | 0.68 | ALOX5 (0.41) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555068-B1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1996-04-10 | — | — | EP | disclosed |
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0555068-A1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |