Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9050356 | 0.90 | MAPT (0.60) | MAPTTP53KMT2AMEN1NPC1 | |
| SCHEMBL9051722 | 0.88 | MAPT (0.49) | MAPTTP53KMT2AMEN1NPC1 | |
| SCHEMBL9049682 | 0.83 | MAPT (0.66) | MAPTTP53KMT2AMEN1NPC1 | |
| SCHEMBL9047596 | 0.83 | MAPT (0.66) | MAPTTP53KMT2AMEN1NPC1 | |
| SCHEMBL9049138 | 0.78 | KMT2A (0.61) | MAPTTP53KMT2AMEN1NPC1 | |
| SCHEMBL9048168 | 0.78 | KMT2A (0.56) | MAPTTP53KMT2AMEN1NPC1 | |
| SCHEMBL9049410 | 0.76 | KMT2A (0.55) | MAPTTP53KMT2AMEN1NPC1 | |
| SCHEMBL9050003 | 0.75 | KMT2A (0.64) | MAPTTP53KMT2AMEN1NPC1 | |
| SCHEMBL14985510 | 0.73 | RAB9A (0.64) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL22415356 | 0.73 | KMT2A (0.56) | MAPTKMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731796-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | disclosed |
| WO-1995015318-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |