Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047596 | 1.00 | MAPT (0.66) | MAPTTP53KMT2ANPC1RAB9A | |
| SCHEMBL14985510 | 0.91 | RAB9A (0.64) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL1608472 | 0.89 | RAB9A (0.62) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL9048168 | 0.85 | KMT2A (0.56) | MAPTTP53KMT2ANPC1RAB9A | |
| SCHEMBL6231163 | 0.84 | RAB9A (0.79) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL25430210 | 0.84 | RAB9A (0.79) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL19131260 | 0.84 | RAB9A (0.79) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL9050356 | 0.84 | MAPT (0.60) | MAPTTP53KMT2ANPC1RAB9A | |
| SCHEMBL9049417 | 0.83 | MAPT (0.59) | MAPTTP53KMT2ANPC1RAB9A | |
| SCHEMBL9051722 | 0.83 | MAPT (0.49) | MAPTTP53KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731796-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | claimed |
| WO-1995015318-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | claimed |