Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PPM1B | O75688 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | ANPEP | P15144 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9127247 | 1.00 | CYP1A2 (0.35) | CYP1A2HIF1AALDH1A1BRD4PPM1B | |
| SCHEMBL25761556 | 1.00 | CYP1A2 (0.35) | CYP1A2HIF1AALDH1A1BRD4PPM1B | |
| SCHEMBL13144523 | 0.78 | HCAR2 (0.30) | — | |
| SCHEMBL3965988 | 0.73 | CYP1A2 (0.39) | CYP1A2HIF1AALDH1A1BRD4PPM1B | |
| SCHEMBL3969491 | 0.72 | CYP1A2 (0.34) | CYP1A2HIF1AALDH1A1BRD4PPM1B | |
| SCHEMBL2784766 | 0.70 | BRD4 (0.44) | CYP1A2HIF1AALDH1A1BRD4MMP2 | |
| SCHEMBL13882832 | 0.70 | CYP1A2 (0.46) | CYP1A2HIF1AALDH1A1BRD4PPM1B | |
| SCHEMBL21704556 | 0.69 | CACNA1G (0.42) | ALDH1A1KMT2A | |
| SCHEMBL27868499 | 0.69 | BRD4 (0.42) | CYP1A2HIF1AALDH1A1BRD4MMP2 | |
| SCHEMBL5346726 | 0.68 | CYP1A2 (0.41) | CYP1A2HIF1AALDH1A1BRD4PPM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555068-B1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1996-04-10 | — | — | EP | disclosed |
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0555068-A1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |