Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 19/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 6/20 | 0.53 |
| ▸ | ACACB | O00763 | 1/20 | 0.50 |
| ▸ | ACACA | Q13085 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9055523 | 0.85 | ACACB (0.65) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9046363 | 0.83 | ALOX5 (0.55) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9048145 | 0.83 | ALOX5 (0.59) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9047623 | 0.81 | ACACB (0.55) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL7206818 | 0.81 | ALOX5 (0.64) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9049738 | 0.81 | ALOX5 (0.60) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9049981 | 0.79 | ALOX5 (0.51) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL9045275 | 0.79 | ACACB (0.53) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL8303854 | 0.78 | ALOX5 (0.66) | ALOX5EPHX2ACACBACACA | |
| SCHEMBL8303850 | 0.78 | ALOX5 (0.66) | ALOX5EPHX2ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | claimed |
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |