Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9048558 | 0.76 | BACE1 (0.36) | BACE1 | |
| SCHEMBL17151565 | 0.69 | OPRL1 (0.47) | BACE1OPRL1ALOX15HPGD | |
| SCHEMBL9049881 | 0.68 | OPRL1 (0.49) | BACE1OPRL1 | |
| SCHEMBL9048334 | 0.66 | — | — | |
| SCHEMBL14860791 | 0.66 | OPRL1 (0.35) | OPRL1 | |
| SCHEMBL1356638 | 0.65 | OPRL1 (0.53) | OPRL1 | |
| SCHEMBL2018541 | 0.65 | OPRL1 (0.33) | OPRL1 | |
| SCHEMBL8553060 | 0.65 | — | — | |
| SCHEMBL29946411 | 0.65 | OPRL1 (0.35) | OPRL1 | |
| SCHEMBL743084 | 0.65 | OPRL1 (0.46) | OPRL1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555068-B1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1996-04-10 | — | — | EP | disclosed |
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0555068-A1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |