Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 9/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.47 |
| ▸ | GRM5 | P41594 | 7/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.47 |
| ▸ | GABRP | O00591 | 6/20 | 0.47 |
| ▸ | GABRD | O14764 | 6/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 6/20 | 0.47 |
| ▸ | GABRE | P78334 | 6/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9050937 | 0.85 | GABRG2 (0.42) | GABRG2GABRB3GABRA5GRM5GABRA1 | |
| SCHEMBL9046799 | 0.80 | GABRG2 (0.48) | GABRG2GABRB3GABRA5GRM5GABRA1 | |
| SCHEMBL4046321 | 0.79 | GABRG2 (0.73) | GABRG2GABRB3GABRA5GRM5GABRA1 | |
| SCHEMBL9051979 | 0.74 | GABRG2 (0.37) | GABRG2GABRB3GABRA5GRM5GABRA1 | |
| SCHEMBL9263243 | 0.73 | GABRG2 (0.71) | GABRG2GABRB3GABRA5GRM5GABRA1 | |
| SCHEMBL7390611 | 0.69 | GABRG2 (0.43) | GABRG2GABRB3GABRA5GRM5GABRA1 | |
| SCHEMBL9371543 | 0.68 | GABRG2 (0.48) | GABRG2GABRB3GABRA5GRM5GABRA1 | |
| SCHEMBL10571474 | 0.68 | GABRG2 (0.74) | GABRG2GABRB3GABRA5GRM5GABRA1 | |
| SCHEMBL10570174 | 0.67 | GABRG2 (0.76) | GABRG2GABRB3GABRA5GRM5GABRA1 | |
| SCHEMBL9669365 | 0.67 | GABRG2 (0.80) | GABRG2GABRB3GABRA5GRM5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0362942-B1 | Benzoxazepinone process | MERCK SHARP & DOHME (GB) | 1996-07-10 | — | — | EP | disclosed |
| US-4977258-A | Benzoxazepinone process | MERCK, SHARP & DOHME LTD. (GB) | 1990-12-11 | — | — | US | disclosed |
| EP-0362942-A2 | Benzoxazepinone process | MERCK SHARP & DOHME LTD. (GB) | 1990-04-11 | — | — | EP | disclosed |