Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 3/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049106 | 0.87 | GABRG2 (0.36) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9048059 | 0.82 | GABRG2 (0.39) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7135694 | 0.81 | GABRA1 (0.57) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9263361 | 0.75 | GABRG2 (0.66) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9050137 | 0.74 | GABRG2 (0.47) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7387921 | 0.72 | GABRA1 (0.47) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7395119 | 0.70 | GABRG2 (0.54) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7427139 | 0.70 | GABRA1 (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL8872561 | 0.70 | GABRA1 (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7395614 | 0.70 | GABRA1 (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0362942-B1 | Benzoxazepinone process | MERCK SHARP & DOHME (GB) | 1996-07-10 | — | — | EP | disclosed |
| US-4977258-A | Benzoxazepinone process | MERCK, SHARP & DOHME LTD. (GB) | 1990-12-11 | — | — | US | disclosed |