Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GLI1 | P08151 | 1/20 | 0.38 |
| ▸ | GLI2 | P10070 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11147918 | 0.84 | PTGS1 (0.54) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL15151142 | 0.81 | PTGS1 (0.58) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL8692714 | 0.80 | THRB (0.40) | KMT2AALDH1A1TSHR | |
| SCHEMBL9558369 | 0.80 | PTGS1 (0.47) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL8577668 | 0.77 | PTGS1 (0.57) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL10745562 | 0.77 | PTGS1 (0.57) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL10550089 | 0.77 | PTGS1 (0.57) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL10686594 | 0.77 | PTGS1 (0.57) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL11202378 | 0.77 | PTGS1 (0.53) | PTGS1MEN1CYP2D6KMT2AALOX5 | |
| SCHEMBL11128330 | 0.77 | PTGS1 (0.53) | PTGS1MEN1CYP2D6KMT2AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |