Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9076775 | 0.88 | ALOX5 (0.32) | ALOX5 | |
| SCHEMBL9076779 | 0.88 | ALOX5 (0.32) | ALOX5 | |
| SCHEMBL9075901 | 0.83 | ITK (0.33) | ITKNTRK1 | |
| SCHEMBL9047915 | 0.82 | ALOX5 (0.57) | ALOX5HPGDLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL9045913 | 0.80 | ALOX5 (0.53) | ALOX5HPGDLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL9050650 | 0.80 | ALOX5 (0.53) | ALOX5HPGDLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL9050252 | 0.79 | ALOX5 (0.41) | ALOX5HPGDLMNAL3MBTL1ITK | |
| SCHEMBL9076868 | 0.78 | ITK (0.32) | ITKNTRK1 | |
| SCHEMBL9076782 | 0.74 | — | — | |
| SCHEMBL9049631 | 0.73 | HPGD (0.39) | ALOX5HPGDLMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555068-B1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1996-04-10 | — | — | EP | disclosed |
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0555068-A1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |