Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 10/20 | 0.33 |
| ▸ | TXK | P42681 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 3/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9076868 | 0.92 | ITK (0.32) | ITKTXKJAK3BTKNTRK1 | |
| SCHEMBL9076775 | 0.85 | ALOX5 (0.32) | — | |
| SCHEMBL9076779 | 0.85 | ALOX5 (0.32) | — | |
| SCHEMBL9076782 | 0.85 | — | — | |
| SCHEMBL9050480 | 0.83 | ALOX5 (0.38) | ITKNTRK1 | |
| SCHEMBL9051154 | 0.76 | — | — | |
| SCHEMBL9077334 | 0.74 | — | — | |
| SCHEMBL9051562 | 0.71 | ALOX5 (0.38) | ITKNTRK1 | |
| SCHEMBL9076523 | 0.70 | ALOX5 (0.34) | — | |
| SCHEMBL9076525 | 0.70 | ALOX5 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |