Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049476 | 0.77 | BACE1 (0.35) | BACE1KCNH2SLC6A2SLC6A4KCNA3 | |
| SCHEMBL9086686 | 0.75 | KCNA3 (0.40) | CHRM1SIGMAR1SLC6A2SLC6A4HCAR3 | |
| SCHEMBL11063102 | 0.74 | CHRM1 (0.40) | CHRM1SLC6A2SLC6A4 | |
| SCHEMBL27437731 | 0.74 | — | — | |
| SCHEMBL8553649 | 0.73 | OPRM1 (0.40) | BACE1CHRM1 | |
| SCHEMBL1310070 | 0.72 | — | — | |
| SCHEMBL8553527 | 0.72 | CHRNA1 (0.39) | SLC6A2SLC6A4 | |
| SCHEMBL9197051 | 0.72 | CHRNA1 (0.39) | SLC6A2SLC6A4 | |
| SCHEMBL9229582 | 0.72 | OPRK1 (0.41) | SLC6A2SLC6A4 | |
| SCHEMBL12638735 | 0.72 | OPRK1 (0.41) | SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555068-B1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1996-04-10 | — | — | EP | disclosed |
| US-5482966-A | LIPOXYGENASE ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 1996-01-09 | — | — | US | disclosed |
| EP-0681576-A1 | OXIME DERIVATIVES | ZENECA LIMITED (GB) | 1995-11-15 | — | — | EP | disclosed |
| WO-1994017054-A1 | OXIME DERIVATIVES | ZENECA LIMITED (GB) | 1994-08-04 | — | — | WO | disclosed |
| US-5332757-A | Enzyme inhibitors | ZENECA LIMITED (GB) | 1994-07-26 | — | — | US | disclosed |
| EP-0555068-A1 | Oxime derivatives as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1993-08-11 | — | — | EP | disclosed |