Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | EYA2 | O00167 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19615405 | 0.92 | TDP1 (0.32) | TSHRTDP1EYA2APPACE | |
| SCHEMBL3230784 | 0.90 | EYA2 (0.31) | TSHRTDP1EYA2APPACE | |
| SCHEMBL28428366 | 0.82 | TDP1 (0.33) | TSHRTDP1EYA2APPACE | |
| SCHEMBL4868996 | 0.79 | TSHR (0.35) | TSHRTDP1EYA2APPACE | |
| SCHEMBL395403 | 0.75 | TDP1 (0.37) | TSHRTDP1EYA2APPACE | |
| SCHEMBL3753416 | 0.74 | CAMK2A (0.41) | — | |
| SCHEMBL3488260 | 0.74 | — | — | |
| SCHEMBL3756453 | 0.72 | — | — | |
| SCHEMBL455742 | 0.72 | CA12 (0.46) | TSHRTDP1APPALOX15HSD17B10 | |
| SCHEMBL31662731 | 0.72 | TDP1 (0.35) | TSHRTDP1EYA2APPACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976185-B1 | HECT E3 LIGASE INHIBITORS AND USES THEREOF | IFOM ST FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS (IT) | 2024-02-14 | — | — | EP | disclosed |
| EP-3976185-A1 | HECT E3 LIGASE INHIBITORS AND USES THEREOF | IFOM - Fondazione Istituto FIRC di Oncologia Molecolare (IT) | 2022-04-06 | — | — | EP | disclosed |
| WO-2020245213-A1 | HECT E3 LIGASE INHIBITORS AND USES THEREOF | IFOM - FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (IT) | 2020-12-10 | — | — | WO | disclosed |
| WO-1996033162-A1 | COMPOUNDS CONTAINING A SUBSTANTIALLY PLANAR, FUSED RING SYSTEM WITH AT LEAST 4 AROMATIC RINGS AND THEIR USE AS A CHIRAL STATIONARY PHASE IN ENANTIOMERIC SEPARATION | RHONE-POULENC LIMITED (GB) | 1996-10-24 | — | — | WO | disclosed |