Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.55 |
| ▸ | EDNRA | P25101 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 15/20 | 0.54 |
| ▸ | PPARA | Q07869 | 15/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7410289 | 0.90 | PPARG (0.50) | EDNRBEDNRAPPARGPPARA | |
| SCHEMBL9058136 | 0.89 | EDNRB (0.56) | EDNRBEDNRAPPARGPPARA | |
| SCHEMBL9126741 | 0.87 | PPARG (0.47) | EDNRBEDNRAPPARGPPARA | |
| SCHEMBL9127085 | 0.80 | EDNRB (0.51) | EDNRBEDNRAPPARGPPARA | |
| SCHEMBL7414833 | 0.79 | PPARG (0.51) | EDNRBEDNRAPPARGPPARA | |
| SCHEMBL9168065 | 0.78 | PPARG (0.40) | EDNRBEDNRAPPARGPPARA | |
| SCHEMBL7408292 | 0.78 | PPARG (0.50) | EDNRBEDNRAPPARGPPARA | |
| SCHEMBL7445885 | 0.76 | PPARG (0.71) | PPARGPPARA | |
| SCHEMBL9128470 | 0.76 | PPARG (0.47) | EDNRBEDNRAPPARGPPARA | |
| SCHEMBL9447429 | 0.75 | CHRM1 (0.52) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0515535-A4 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5420133-A | Quinazolinones substituted with phenoxyphenylacetic acid derivatives | MERCK & CO., INC. (US) | 1995-05-30 | — | — | US | disclosed |
| US-5401745-A | Cardiovascular disorders or hypotensive agents | MERCK & CO., INC. (US) | 1995-03-28 | — | — | US | disclosed |
| WO-1994021259-A1 | QUINAZOLINONES SUBSTITUTED WITH PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1994-09-29 | — | — | WO | disclosed |
| US-5264439-A | Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element | MERCK & CO., INC. (US) | 1993-11-23 | — | — | US | disclosed |
| EP-0515535-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO. INC. (US) | 1992-12-02 | — | — | EP | disclosed |
| WO-1991012001-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO., INC. (US) | 1991-08-22 | — | — | WO | disclosed |