Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661339 | 0.80 | ALDH1A1 (0.42) | HTTMAOBMAOAALDH1A1MAPT | |
| SCHEMBL9049539 | 0.78 | ALDH1A1 (0.43) | HTTDAOALDH1A1HRH3RAB9A | |
| SCHEMBL9050747 | 0.77 | SMN1; SMN2 (0.55) | DAOBCHEACHEIDO1MAOB | |
| SCHEMBL9048067 | 0.77 | CA12 (0.44) | HTTEPHX1ALDH1A1TP53 | |
| SCHEMBL9046628 | 0.76 | CYP1A2 (0.50) | HTTBCHEACHEIDO1EPHX1 | |
| SCHEMBL8660050 | 0.72 | ALDH1A1 (0.39) | MAOBMAOAALDH1A1ACEMAPT | |
| SCHEMBL8660046 | 0.72 | ALDH1A1 (0.39) | MAOBMAOAALDH1A1ACEMAPT | |
| SCHEMBL5935684 | 0.72 | ALDH1A1 (0.42) | ALDH1A1MAPT | |
| SCHEMBL13103908 | 0.72 | ALDH1A1 (0.42) | ALDH1A1MAPT | |
| SCHEMBL4597178 | 0.72 | HTT (0.66) | HTTDAOBCHEACHEIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660826-A4 | 5,5-DISUBSTITUTED HYDANTOINS. | SOUTHERN RES INST (US) | 1996-07-31 | — | — | EP | disclosed |
| EP-0660826-A1 | 5,5-DISUBSTITUTED HYDANTOINS | SOUTHERN RESEARCH INSTITUTE (US) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006775-A1 | 5,5-DISUBSTITUTED HYDANTOINS | SOUTHERN RESEARCH INSTITUTE (US) | 1994-03-31 | — | — | WO | disclosed |