Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.45 |
| ▸ | DRD1 | P21728 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402811 | 0.84 | DRD2 (0.46) | DRD2DRD3HTR1ADRD4DRD1 | |
| SCHEMBL7405539 | 0.83 | ALDH1A1 (0.53) | DRD2DRD3HTR1ALMNADRD4 | |
| SCHEMBL7403486 | 0.83 | DRD2 (0.50) | DRD2DRD3HTR1ADRD4DRD1 | |
| SCHEMBL7404378 | 0.82 | MAPT (0.52) | DRD2HTR1ADRD4POLBHTR2A | |
| Hydrochloric Acid SCHEMBL8185523 | 0.82 | ALDH1A1 (0.52) | DRD2DRD3HTR1ALMNADRD4 | |
| Hydrochloric Acid SCHEMBL7401818 | 0.81 | MAPT (0.51) | DRD2HTR1ADRD4POLBHTR2A | |
| SCHEMBL27524409 | 0.78 | DRD2 (0.69) | DRD2DRD3HTR1ADRD4DRD1 | |
| SCHEMBL7401374 | 0.78 | DRD2 (0.48) | DRD2DRD3HTR1ADRD4DRD1 | |
| SCHEMBL7397854 | 0.78 | DRD4 (0.68) | DRD2HTR1ADRD4HTR2AADRA1A | |
| Hydrochloric Acid SCHEMBL8185604 | 0.77 | DRD4 (0.67) | DRD2HTR1ADRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0737189-A1 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CNS AND CARDIOVASCULAR DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-10-16 | — | — | EP | disclosed |