Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15145325 | 0.84 | P2RX7 (0.52) | P2RX7HPGDEPHX2CYP2D6MAPT | |
| Hypochlorous Acid SCHEMBL11153596 | 0.78 | ABAT (0.50) | HPGDEPHX2MAPTSMN1; SMN2MEN1 | |
| Benzene SCHEMBL27714747 | 0.78 | ABAT (0.53) | HPGDEPHX2MAPTSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL2006870 | 0.78 | ABAT (0.53) | HPGDEPHX2MAPTSMN1; SMN2MEN1 | |
| SCHEMBL1330698 | 0.78 | ABAT (0.53) | HPGDEPHX2MAPTSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL3069393 | 0.78 | ABAT (0.53) | HPGDEPHX2MAPTSMN1; SMN2MEN1 | |
| SCHEMBL41828 | 0.78 | ABAT (0.53) | HPGDEPHX2MAPTSMN1; SMN2MEN1 | |
| SCHEMBL7785939 | 0.78 | ABAT (0.53) | HPGDEPHX2MAPTSMN1; SMN2MEN1 | |
| Biphenyl SCHEMBL28946850 | 0.77 | MEN1 (0.55) | P2RX7HPGDEPHX2MAPTMEN1 | |
| Fluoride SCHEMBL7426005 | 0.76 | ABAT (0.52) | HPGDEPHX2MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2272825-B1 | Protected amino hydroxy adamantane carboxylic acid and process for its preparation | ASTRAZENECA AB (SE) | 2015-11-04 | — | — | EP | claimed |
| EP-2272825-A2 | N-Protected amino hydroxy adamantane carboxylic acid and process for its preparation | Bristol-Myers Squibb Company (US) | 2011-01-12 | — | — | EP | claimed |
| EP-1559710-A2 | Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV, process for their preparation and their use | Bristol-Myers Squibb Company (US) | 2005-08-03 | — | — | EP | claimed |