Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6989535 | 0.77 | NPC1 (0.54) | NPC1RAB9AMETAP2ADRA2AMAOB | |
| SCHEMBL5020207 | 0.69 | NPC1 (0.59) | NPC1RAB9AMETAP2ADRA2AMAOB | |
| SCHEMBL30036439 | 0.69 | MAOB (0.63) | NPC1RAB9AMETAP2ADRA2AMAOB | |
| SCHEMBL103158 | 0.69 | MAOB (0.63) | NPC1RAB9AMETAP2ADRA2AMAOB | |
| SCHEMBL29722878 | 0.67 | MAPT (0.69) | NPC1RAB9AMETAP2ADRA2AMAOB | |
| SCHEMBL26905312 | 0.67 | MAPT (0.69) | NPC1RAB9AMETAP2ADRA2AMAOB | |
| SCHEMBL17843529 | 0.66 | NPC1 (0.56) | NPC1RAB9AMETAP2ADRA2AMAOB | |
| SCHEMBL23430130 | 0.66 | KDM4E (0.45) | NPC1RAB9AMAOBKDM4EALDH1A1 | |
| SCHEMBL30561833 | 0.66 | MAOB (0.55) | NPC1RAB9AMETAP2ADRA2AMAOB | |
| SCHEMBL15468601 | 0.66 | LRRK2 (0.42) | NPC1RAB9AMETAP2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731795-A1 | SUBSTITUTED PYRAZOLYL BENZENESULFONAMIDES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | disclosed |