Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 4/20 | 0.68 |
| ▸ | HTR2C | P28335 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | HTR2A | P28223 | 2/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | PKM | P14618 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.68 |
| ▸ | THPO | P40225 | 1/20 | 0.68 |
| ▸ | HTR2B | P41595 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616711 | 0.87 | NPC1 (0.60) | NPC1RAB9AHTR2CMAPTMEN1 | |
| SCHEMBL9052182 | 0.86 | MAPT (0.62) | NPC1RAB9AHTR2CMAPTMEN1 | |
| SCHEMBL9051246 | 0.86 | HTR2C (0.70) | NPC1RAB9AHTR2CMAPTMEN1 | |
| SCHEMBL9051316 | 0.85 | RAB9A (0.69) | NPC1RAB9AHTR2CMAPTMEN1 | |
| SCHEMBL9052562 | 0.84 | NPC1 (0.68) | NPC1RAB9AHTR2CMAPTMEN1 | |
| SCHEMBL9116372 | 0.84 | HTR2C (0.68) | NPC1RAB9AHTR2CMAPTMEN1 | |
| SCHEMBL9053646 | 0.83 | HTR2C (0.67) | NPC1RAB9AHTR2CMAPTMEN1 | |
| SCHEMBL9053122 | 0.83 | MEN1 (0.52) | NPC1RAB9AHTR2CMAPTMEN1 | |
| SCHEMBL29369443 | 0.81 | HTR2C (1.00) | NPC1RAB9AHTR2CMAPTMEN1 | |
| SCHEMBL1459242 | 0.81 | HTR2C (1.00) | NPC1RAB9AHTR2CMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743946-A1 | 5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES | SMITHKLINE BEECHAM PLC (GB) | 1996-11-27 | — | — | EP | claimed |
| WO-1995021844-A1 | 5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES | SMITHKLINE BEECHAM PLC (GB) | 1995-08-17 | — | — | WO | claimed |
| EP-0743946-A1 | 5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES | SMITHKLINE BEECHAM PLC (GB) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021844-A1 | 5HT2B RECEPTOR ANTAGONISTS CONDENSED INDOLES | SMITHKLINE BEECHAM PLC (GB) | 1995-08-17 | — | — | WO | disclosed |