Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5624032 | 0.82 | HTR2A (0.41) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL28029187 | 0.76 | HTR2A (0.40) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL5338566 | 0.75 | SLC6A2 (0.48) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL30637279 | 0.75 | HTR2A (0.42) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL6616733 | 0.75 | ADRB2 (0.39) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL27948442 | 0.74 | PLAU (0.39) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL5346300 | 0.73 | SLC6A2 (0.41) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL15416051 | 0.73 | SLC6A2 (0.37) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 | |
| SCHEMBL28798379 | 0.72 | DRD2 (0.42) | — | |
| SCHEMBL27854563 | 0.72 | SLC6A2 (0.42) | HTR2ASLC6A4SLC6A2HTR2BSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | claimed |