Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.60 |
| ▸ | EDNRB | P24530 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CCR4 | P51679 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045980 | 0.84 | MEN1 (0.47) | EDNRAEDNRBMEN1KMT2AALDH1A1 | |
| SCHEMBL9045435 | 0.83 | EDNRA (0.60) | EDNRAEDNRBMEN1KMT2AALDH1A1 | |
| SCHEMBL9045266 | 0.82 | EDNRA (0.79) | EDNRAEDNRBMEN1KMT2AALDH1A1 | |
| SCHEMBL9045035 | 0.79 | EDNRA (0.61) | EDNRAEDNRBMEN1KMT2AALDH1A1 | |
| SCHEMBL9045073 | 0.76 | EDNRA (0.62) | EDNRAEDNRB | |
| SCHEMBL9046616 | 0.76 | EDNRA (0.59) | EDNRAEDNRBSMN1; SMN2POLB | |
| SCHEMBL9045531 | 0.76 | EDNRA (0.64) | EDNRAEDNRBMEN1KMT2AALDH1A1 | |
| SCHEMBL9044052 | 0.75 | EDNRA (0.89) | EDNRAEDNRB | |
| SCHEMBL9044159 | 0.75 | EDNRA (0.58) | EDNRAEDNRBPIK3CG | |
| SCHEMBL9043320 | 0.75 | EDNRA (0.80) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |