Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | FBP1 | P09467 | 2/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052960 | 0.84 | EDNRA (0.60) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9045459 | 0.80 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1POLBEDNRB | |
| SCHEMBL9496187 | 0.77 | ALDH1A1 (0.63) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL9045082 | 0.77 | SMN1; SMN2 (0.54) | KMT2AALDH1A1HPGDSMN1; SMN2BACE1 | |
| SCHEMBL9044255 | 0.76 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9044490 | 0.75 | EDNRA (0.45) | MEN1KMT2AALDH1A1POLBEDNRB | |
| SCHEMBL9047760 | 0.72 | EDNRA (0.42) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9048076 | 0.72 | KDM4E (0.49) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9046333 | 0.71 | MAPT (0.45) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9046239 | 0.71 | EDNRA (0.40) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| US-5270313-A | Treatment of circulatory disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |