Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 5/20 | 0.60 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.60 |
| ▸ | AGT | P01019 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9243143 | 0.95 | AGTR1 (0.54) | AGTR1AGTR2AGTLMNASMN1; SMN2 | |
| SCHEMBL9248172 | 0.94 | AGTR1 (0.54) | AGTR1AGTR2AGTLMNASMN1; SMN2 | |
| SCHEMBL9042305 | 0.88 | AGTR1 (0.59) | AGTR1AGTR2AGT | |
| SCHEMBL9142860 | 0.83 | AGTR1 (0.54) | AGTR1AGTR2AGT | |
| SCHEMBL9140676 | 0.81 | AGTR1 (0.54) | AGTR1AGTR2AGT | |
| SCHEMBL17031411 | 0.81 | AGTR1 (0.57) | AGTR1AGTR2AGT | |
| SCHEMBL14855564 | 0.80 | AGTR1 (0.56) | AGTR1AGTR2AGTLMNAALDH1A1 | |
| SCHEMBL13679193 | 0.79 | AGTR1 (0.55) | AGTR1AGTR2AGTALDH1A1HPGD | |
| SCHEMBL1966667 | 0.78 | AGTR1 (0.54) | AGTR1AGTR2AGT | |
| SCHEMBL1968567 | 0.78 | AGTR1 (0.54) | AGTR1AGTR2AGT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531876-B1 | Imidazoindolizine derivatives and process for preparation thereof | TANABE SEIYAKU CO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5268377-A | Imidazoindolizine derivatives process for preparation thereof and use thereof to treat hypertension | TANABE SEIYAKU CO., LTD. (JP) | 1993-12-07 | — | — | US | disclosed |
| EP-0531876-A2 | Imidazoindolizine derivatives and process for preparation thereof | TANABE SEIYAKU CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |