Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097058 | 0.83 | SMN1; SMN2 (0.69) | MAPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9053644 | 0.81 | SMN1; SMN2 (0.78) | MAPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6097848 | 0.79 | MAPT (0.61) | MAPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL6096534 | 0.78 | GAA (0.73) | MAPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8721765 | 0.77 | MAPT (0.62) | MAPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL21131436 | 0.76 | RAPGEF4 (0.47) | MAPTGAAALDH1A1KMT2AKDM4E | |
| SCHEMBL10784655 | 0.73 | SMN1; SMN2 (0.58) | MAPTALDH1A1SMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL2243625 | 0.73 | GAA (0.70) | MAPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL11855568 | 0.73 | GAA (0.65) | MAPTGAAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8423522 | 0.73 | GAA (0.65) | MAPTGAAALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528146-B1 | N-phenylthiourea derivatives and pharmaceutical use thereof | SANDOZ LTD (CH) | 1996-02-21 | — | — | EP | claimed |
| EP-0528146-A1 | N-phenylthiourea derivatives and pharmaceutical use thereof | SANDOZ LTD. (CH) | 1993-02-24 | — | — | EP | claimed |
| US-7713540-B2 | Devices and methods for reverse lipid transport | MEDTRONIC VASCULAR, INC. (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713540-B2 | Devices and methods for reverse lipid transport | MEDTRONIC VASCULAR, INC. (US) | 2010-05-11 | — | — | US | disclosed |
| US-20090208549-A1 | Devices and Methods for Reverse Lipid Transport | MEDTRONIC VASCULAR, INC. (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090208549-A1 | Devices and Methods for Reverse Lipid Transport | MEDTRONIC VASCULAR, INC. (US) | 2009-08-20 | — | — | US | disclosed |
| EP-0528146-B1 | N-phenylthiourea derivatives and pharmaceutical use thereof | SANDOZ LTD (CH) | 1996-02-21 | — | — | EP | disclosed |
| EP-0528146-A1 | N-phenylthiourea derivatives and pharmaceutical use thereof | SANDOZ LTD. (CH) | 1993-02-24 | — | — | EP | disclosed |