Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.78 |
| ▸ | LMNA | P02545 | 5/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ALPL | P05186 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097058 | 0.88 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAMAPTGAAHTT | |
| SCHEMBL9054497 | 0.82 | POLB (0.64) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL9053597 | 0.81 | MAPT (0.61) | SMN1; SMN2LMNAMAPTGAAHTT | |
| SCHEMBL6097848 | 0.81 | MAPT (0.61) | SMN1; SMN2LMNAMAPTGAAHTT | |
| SCHEMBL6096534 | 0.79 | GAA (0.73) | SMN1; SMN2LMNAMAPTGAAALDH1A1 | |
| SCHEMBL8721765 | 0.78 | MAPT (0.62) | SMN1; SMN2LMNAMAPTGAAHTT | |
| SCHEMBL14054918 | 0.78 | L3MBTL1 (0.76) | SMN1; SMN2LMNAMAPTHTTALDH1A1 | |
| SCHEMBL27761076 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNAMAPTGAAHTT | |
| SCHEMBL11757368 | 0.76 | SMN1; SMN2 (0.78) | SMN1; SMN2LMNAMAPTHTTALDH1A1 | |
| SCHEMBL4346806 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAMAPTGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528146-B1 | N-phenylthiourea derivatives and pharmaceutical use thereof | SANDOZ LTD (CH) | 1996-02-21 | — | — | EP | claimed |
| EP-0528146-A1 | N-phenylthiourea derivatives and pharmaceutical use thereof | SANDOZ LTD. (CH) | 1993-02-24 | — | — | EP | claimed |
| JP-5221959-A | — | — | None | — | — | JP | disclosed |
| EP-0528146-B1 | N-phenylthiourea derivatives and pharmaceutical use thereof | SANDOZ LTD (CH) | 1996-02-21 | — | — | EP | disclosed |
| JP-H05221959-A | N-PHENYTHIOUREA DERIVATIVE AND ITS PHERMACEUTICAL USE | SANDOZ AG | 1993-08-31 | — | — | JP | disclosed |
| EP-0528146-A1 | N-phenylthiourea derivatives and pharmaceutical use thereof | SANDOZ LTD. (CH) | 1993-02-24 | — | — | EP | disclosed |