Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.52 |
| ▸ | RARG | P13631 | 6/20 | 0.52 |
| ▸ | RARA | P10276 | 5/20 | 0.52 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | HNF4A | P41235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289444 | 0.84 | RARB (0.55) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL29616597 | 0.78 | RARA (0.48) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL2599701 | 0.78 | RARA (0.48) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL13417226 | 0.78 | RARB (0.58) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL18211725 | 0.76 | MAP3K14 (0.50) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL8293244 | 0.76 | RARA (0.49) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL23266155 | 0.75 | RARA (0.46) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL3521982 | 0.75 | ALDH1A1 (0.47) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL3998188 | 0.75 | CYP26A1 (0.49) | RARBRARGRARARXRACYP26A1 | |
| SCHEMBL10935850 | 0.75 | RARB (0.72) | RARBRARGRARARXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996006070-A1 | DISUBSTITUTED ARYL AND HETEROARYL IMINES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-02-29 | — | — | WO | disclosed |