Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29780034 | 0.87 | LMNA (0.49) | LMNAMAPK1TSHRMAPTRECQL | |
| SCHEMBL12186945 | 0.87 | LMNA (0.49) | LMNAMAPK1TSHRMAPTRECQL | |
| SCHEMBL9053874 | 0.87 | LMNA (0.49) | LMNAMAPK1TSHRMAPTRECQL | |
| SCHEMBL9053850 | 0.81 | LMNA (0.48) | LMNAMAPK1TSHRMAPTRECQL | |
| SCHEMBL9053600 | 0.70 | LMNA (0.35) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9054126 | 0.70 | LMNA (0.36) | LMNAMAPTALDH1A1POLBKMT2A | |
| SCHEMBL11819614 | 0.70 | LMNA (0.61) | LMNAMAPK1TSHRMAPTRECQL | |
| SCHEMBL11819609 | 0.70 | LMNA (0.61) | LMNAMAPK1TSHRMAPTRECQL | |
| SCHEMBL9053194 | 0.69 | EGFR (0.40) | LMNAMAPTALDH1A1POLBKMT2A | |
| SCHEMBL16123024 | 0.68 | LMNA (0.50) | LMNAMAPK1TSHRMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508955-B1 | Use of 2-iminothiazolidin-4-one derivatives as new medicaments | CIBA GEIGY AG (CH) | 1996-06-19 | — | — | EP | claimed |
| US-5229405-A | Rheumatic diseases | CIBA-GEIGY CORPORATION (US) | 1993-07-20 | — | — | US | disclosed |