Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29780034 | 0.82 | LMNA (0.49) | LMNACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9053874 | 0.82 | LMNA (0.49) | LMNACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL12186945 | 0.82 | LMNA (0.49) | LMNACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9053194 | 0.82 | EGFR (0.40) | LMNACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9054126 | 0.80 | LMNA (0.36) | LMNACYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9152818 | 0.76 | ALDH1A1 (0.30) | ALDH1A1MAPT | |
| SCHEMBL9054287 | 0.76 | ALDH1A1 (0.30) | ALDH1A1MAPT | |
| SCHEMBL9145222 | 0.72 | MEN1 (0.32) | NPSR1ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL10814618 | 0.72 | ALDH1A1 (0.47) | LMNASMN1; SMN2NPSR1GAAHPGD | |
| SCHEMBL9494802 | 0.71 | ALDH1A1 (0.41) | LMNANPSR1GAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508955-B1 | Use of 2-iminothiazolidin-4-one derivatives as new medicaments | CIBA GEIGY AG (CH) | 1996-06-19 | — | — | EP | claimed |
| EP-0508955-A1 | Use of 2-iminothiazolidin-4-one derivatives as new medicaments | CIBA-GEIGY AG (CH) | 1992-10-14 | — | — | EP | claimed |
| EP-0508955-B1 | Use of 2-iminothiazolidin-4-one derivatives as new medicaments | CIBA GEIGY AG (CH) | 1996-06-19 | — | — | EP | disclosed |
| US-5229405-A | Rheumatic diseases | CIBA-GEIGY CORPORATION (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0508955-A1 | Use of 2-iminothiazolidin-4-one derivatives as new medicaments | CIBA-GEIGY AG (CH) | 1992-10-14 | — | — | EP | disclosed |