Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YES1 | P07947 | 2/20 | 0.68 |
| ▸ | KDR | P35968 | 2/20 | 0.68 |
| ▸ | JAK3 | P52333 | 2/20 | 0.68 |
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805573 | 0.89 | HTR2C (0.71) | YES1KDRJAK3HTR2CMAPT | |
| SCHEMBL8804198 | 0.83 | NOTUM (0.62) | YES1KDRJAK3NOTUMMAPT | |
| SCHEMBL9055209 | 0.81 | HTR2C (0.79) | YES1KDRJAK3HTR2CMAPT | |
| SCHEMBL32932963 | 0.81 | YES1 (1.00) | YES1KDRJAK3MAPTPOLB | |
| SCHEMBL21585709 | 0.81 | YES1 (1.00) | YES1KDRJAK3MAPTPOLB | |
| SCHEMBL9055125 | 0.81 | YES1 (0.62) | YES1KDRJAK3MAPTPOLB | |
| SCHEMBL9054761 | 0.80 | YES1 (0.83) | YES1KDRJAK3MAPTPOLB | |
| SCHEMBL26391933 | 0.79 | HTR2C (1.00) | HTR2CMAPTPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL3854264 | 0.79 | TUBB4A (0.67) | HTR2CMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9670003 | 0.79 | POLB (0.60) | YES1KDRJAK3MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996004266-A2 | INDOL, INDAZOL, PYRIDOPYRROL AND PYRIDOPYRAZOL DERIVATIVES WITH ANTI-ASTHMATIC, ANTI-ALLERGIC, ANTI-INFLAMMATORY AND IMMUNOMODULATING EFFECTS | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1996-02-15 | — | — | WO | disclosed |