Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.87 |
| ▸ | NOS3 | P29474 | 2/20 | 0.56 |
| ▸ | NOS2 | P35228 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6280369 | 0.93 | NOS1 (1.00) | NOS1NOS3NOS2KMT2A | |
| Iodide SCHEMBL9053048 | 0.91 | NOS1 (0.96) | NOS1NOS3NOS2KMT2A | |
| Fumaric Acid SCHEMBL9037758 | 0.89 | NOS1 (0.79) | NOS1NOS3NOS2NPC1PKM | |
| Propyne SCHEMBL9046697 | 0.85 | NOS1 (0.84) | NOS1NOS3NOS2 | |
| SCHEMBL27355025 | 0.82 | NOS1 (0.68) | NOS1NOS3NOS2 | |
| SCHEMBL7081205 | 0.81 | NOS1 (0.66) | NOS1NOS3NOS2NPC1HPGD | |
| Iodide SCHEMBL6961526 | 0.81 | NOS1 (0.66) | NOS1NOS3NOS2 | |
| SCHEMBL4628340 | 0.80 | NOS1 (0.73) | NOS1NOS3NOS2NPC1RAB9A | |
| SCHEMBL4409794 | 0.79 | NOS1 (0.74) | NOS1NOS3NOS2 | |
| SCHEMBL8572027 | 0.79 | RAB9A (0.68) | NOS1NPC1HPGDRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | disclosed |