Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 9/20 | 0.40 |
| ▸ | RARB | P10826 | 9/20 | 0.40 |
| ▸ | RARG | P13631 | 9/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9053825 | 0.94 | RARA (0.40) | RARARARBRARGRXRAALDH1A1 | |
| SCHEMBL4666462 | 0.78 | RARG (0.51) | RARARARBRARGRXRAALDH1A1 | |
| SCHEMBL9054067 | 0.76 | RARA (0.38) | RARARARBRARGALDH1A1SMN1; SMN2 | |
| SCHEMBL9092256 | 0.76 | RARA (0.36) | RARARARBRARGRXRAALDH1A1 | |
| SCHEMBL6665606 | 0.76 | RARA (0.36) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL7031739 | 0.75 | RARA (0.46) | RARARARBRARGRXRAALDH1A1 | |
| SCHEMBL8458834 | 0.74 | RXRA (0.50) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL669879 | 0.73 | RARB (0.59) | RARARARBRARGRXRACYP3A4 | |
| SCHEMBL7717570 | 0.73 | RARB (0.46) | RARARARBRARGRXRAALDH1A1 | |
| SCHEMBL9054107 | 0.72 | RARA (0.36) | RARARARBRARGRXRAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498755-A | IMINE COMPOUNDS FOR SKIN DISORDERS AND ANTIINFLAMMATORY AGENTS | ALLERGAN, INC. | 1996-03-12 | — | — | US | disclosed |
| WO-1996006070-A1 | DISUBSTITUTED ARYL AND HETEROARYL IMINES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-02-29 | — | — | WO | disclosed |