Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.60 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.43 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6135986 | 0.91 | ESR1 (0.58) | ESR1ESR2CYP26A1CYP24A1MIF | |
| SCHEMBL3861662 | 0.87 | ESR1 (0.60) | ESR1ESR2CYP26A1CYP24A1MIF | |
| SCHEMBL3862097 | 0.87 | ESR1 (0.52) | ESR1ESR2MAPTKDM4ENPC1 | |
| SCHEMBL9056785 | 0.86 | ESR1 (0.56) | ESR1ESR2HCRTR1HCRTR2MAPT | |
| SCHEMBL11187364 | 0.84 | ESR1 (0.55) | ESR1ESR2MAPTEBPSIGMAR1 | |
| SCHEMBL7107472 | 0.84 | ESR1 (0.52) | ESR1ESR2CYP26A1CYP24A1MIF | |
| SCHEMBL7113206 | 0.84 | ESR1 (0.48) | ESR1ESR2CYP26A1CYP24A1MIF | |
| SCHEMBL7108932 | 0.84 | ESR1 (0.52) | ESR1ESR2CYP26A1CYP24A1MIF | |
| SCHEMBL3861641 | 0.83 | ESR1 (0.55) | ESR1ESR2MAPTKDM4EEBP | |
| SCHEMBL9571848 | 0.82 | ESR1 (0.51) | ESR1ESR2CYP26A1MIFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996009051-A1 | A METHOD FOR MINIMIZING THE UTEROTROPHIC EFFECT OF TAMOXIFEN AND TAMOXIFEN ANALOGS | ELI LILLY AND COMPANY (US) | 1996-03-28 | — | — | WO | disclosed |