Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3097276 | 0.79 | ALDH1A1 (0.41) | HTR6MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9055057 | 0.76 | HTR6 (0.39) | HTR6AHRSLC6A2ADRB2ADRB1 | |
| SCHEMBL16014125 | 0.75 | MEN1 (0.52) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL11095888 | 0.71 | AHR (0.44) | HTR2AHTR2CHTR2BDRD4DRD3 | |
| SCHEMBL27556122 | 0.71 | AHR (0.48) | HTR6HTR2AHTR2CHTR2BDRD4 | |
| SCHEMBL5750791 | 0.71 | SLC6A2 (0.37) | HTR2AHPGDSSLC6A2ADRB2ADRB1 | |
| SCHEMBL3095729 | 0.70 | HRH1 (0.52) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL29777154 | 0.68 | HTR6 (0.43) | HTR6HTR2AHTR2CHTR2BAHR | |
| SCHEMBL10372813 | 0.68 | HTR6 (0.43) | HTR6HTR2AHTR2CHTR2BAHR | |
| SCHEMBL29816334 | 0.67 | AHR (0.43) | HTR6HTR2AHTR2CHTR2BAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545744-A | Cyano naphthalene compounds | AGOURON PHARMACEUTICALS, INC. (US) | 1996-08-13 | — | — | US | disclosed |
| US-5498727-A | Preparation of benzindole compounds from naphthalene compounds | AGOURON PHARMACEUTICALS, INC. (US) | 1996-03-12 | — | — | US | disclosed |
| WO-1996002502-A1 | PREPARATION OF BENZINDOLE COMPOUNDS FROM NAPHTHALENE COMPOUNDS | AGOURON PHARMACEUTICALS, INC. (US) | 1996-02-01 | — | — | WO | disclosed |