Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6162357 | 1.00 | LMNA (0.51) | LMNASRCCTSDPOLBMMP8 | |
| SCHEMBL28777621 | 0.86 | SRC (0.64) | LMNASRCCTSDPOLBMMP8 | |
| SCHEMBL6162055 | 0.81 | KMT2A (0.48) | LMNASRCCTSDMMP8KMT2A | |
| SCHEMBL170040 | 0.80 | SRC (0.67) | LMNASRCCTSDPOLBSMN1; SMN2 | |
| SCHEMBL6575278 | 0.79 | UGT2B7 (0.47) | SMN1; SMN2SLC6A3EPHX1 | |
| SCHEMBL6573647 | 0.79 | UGT2B7 (0.47) | SMN1; SMN2SLC6A3EPHX1 | |
| SCHEMBL6342212 | 0.78 | LMNA (0.46) | LMNACTSDPOLBKMT2ASMN1; SMN2 | |
| SCHEMBL3638914 | 0.78 | LMNA (0.53) | LMNACTSDPOLBKMT2AHDAC3 | |
| SCHEMBL1515665 | 0.78 | LMNA (0.53) | LMNACTSDPOLBKMT2AHDAC3 | |
| SCHEMBL3743441 | 0.78 | LMNA (0.53) | LMNACTSDPOLBKMT2AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996039384-A1 | SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS | PFIZER, INC. (US) | 1996-12-12 | — | — | WO | disclosed |