SCHEMBL6162055

SCHEMBL6162055

CONC(=O)C(C(N)=O)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.48
SRC P12931 1/20 0.47
MMP8 P22894 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.45
CTSD P07339 1/20 0.44
TSHR P16473 2/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2D6 P10635 2/20 0.41
CXCR1 P25024 1/20 0.41
CXCR2 P25025 1/20 0.41
CYP3A4 P08684 1/20 0.41
MAPK1 P28482 1/20 0.41
HSD17B10 Q99714 1/20 0.41
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6162357 0.81 LMNA (0.51) KMT2ASRCMMP8SMN1; SMN2CTSD
SCHEMBL9055207 0.81 LMNA (0.51) KMT2ASRCMMP8SMN1; SMN2CTSD
SCHEMBL2227571 0.81 KMT2A (0.62) KMT2ASRCMMP8SMN1; SMN2TSHR
SCHEMBL3905518 0.81 CTSD (0.62) KMT2ASMN1; SMN2CTSDHDAC3HDAC4
SCHEMBL6344345 0.81 KMT2A (0.53) KMT2ASMN1; SMN2CTSDTSHRCYP1A2
SCHEMBL28711757 0.79 LMNA (0.52) KMT2AMMP8SMN1; SMN2CTSDCXCR1
SCHEMBL6802546 0.79 CXCR1 (0.63) KMT2ACTSDCXCR1CXCR2LMNA
SCHEMBL28711758 0.79 LMNA (0.52) KMT2AMMP8SMN1; SMN2CTSDCXCR1
SCHEMBL11776768 0.78 KMT2A (0.48) KMT2ASMN1; SMN2CTSDTSHRCYP1A2
SCHEMBL170040 0.77 SRC (0.67) SRCSMN1; SMN2CTSDTSHRCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1134213-B1 Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides PFIZER (US) 2005-11-02 EP disclosed
EP-0832065-B1 SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS PFIZER (US) 2001-10-10 EP disclosed
EP-1134213-A2 Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides PFIZER INC. (US) 2001-09-19 EP disclosed
US-6277877-B1 GLYCOGEN PHOSPHORYLASE INHIBITOR; ANTIDIABETIC AGENTS PFIZER, INC. 2001-08-21 US disclosed
US-6107329-A HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS PFIZER, INC. (US) 2000-08-22 US disclosed
EP-0832065-A1 SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS PFIZER INC. (US) 1998-04-01 EP disclosed
WO-1996039384-A1 SUBSTITUTED N-(INDOLE-2-CARBONYL)-GLYCINAMIDES AND DERIVATIVES AS GLYCOGEN PHOSPHORYLASE INHIBITORS PFIZER, INC. (US) 1996-12-12 WO disclosed