Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.51 |
| ▸ | PDE6D | O43924 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 4/20 | 0.50 |
| ▸ | SNCA | P37840 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801364 | 0.86 | ALDH1A1 (0.52) | BACE1APPSNCAHTR6HDAC8 | |
| SCHEMBL27475781 | 0.84 | HDAC8 (0.47) | BACE1APPSNCAHTR6HDAC8 | |
| SCHEMBL9058088 | 0.84 | HDAC8 (0.49) | BACE1APPSNCAHTR6HDAC8 | |
| SCHEMBL28886142 | 0.78 | HTR2A (0.57) | APPSNCAHTR6HDAC8HDAC1 | |
| SCHEMBL6179658 | 0.75 | HDAC1 (0.55) | BACE1APPSNCAHTR6HDAC8 | |
| SCHEMBL8388013 | 0.75 | HDAC8 (0.48) | BACE1APPSNCAHTR6HDAC8 | |
| SCHEMBL6086725 | 0.74 | HDAC8 (0.53) | HDAC8HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL8387304 | 0.74 | HDAC8 (0.55) | BACE1APPSNCAHTR6HDAC8 | |
| SCHEMBL8388261 | 0.74 | HDAC1 (0.50) | BACE1APPSNCAHTR6HDAC8 | |
| SCHEMBL7714740 | 0.73 | BACE1 (0.67) | BACE1APPSNCAHTR6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1166169-A | Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors | SANKYO CO (JP) | 1997-11-26 | — | — | CN | disclosed |
| WO-1996003377-A1 | HETEROCYCLIC COMPOUNDS, USEFUL AS ALLOSTERIC EFFECTORS AT MUSCARINIC RECEPTORS | SANKYO COMPANY, LIMITED (JP) | 1996-02-08 | — | — | WO | disclosed |