Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18692791 | 0.90 | KDM4E (0.62) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL18692790 | 0.90 | KDM4E (0.62) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL9056279 | 0.89 | KDM4E (0.52) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL915761 | 0.81 | MAPT (0.53) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL2488962 | 0.76 | MIF (0.74) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL2488965 | 0.76 | MIF (0.74) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL1573371 | 0.74 | KDM4E (0.67) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL1573369 | 0.74 | KDM4E (0.67) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL9055047 | 0.74 | ALDH1A1 (0.71) | KDM4EMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL18704469 | 0.73 | MAPT (0.67) | KDM4EMAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996012706-A1 | NOVEL ACID PYRAZOLE AND PYRAZOLONE DERIVATIVES FOR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS | ROUSSEL UCLAF (FR) | 1996-05-02 | — | — | WO | disclosed |