L-Citrulline

L-Citrulline

SCHEMBL437142

NC(=O)NCCC[C@@H](N)C(=O)O

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OTC P00480 1/20 0.59
DDAH1 O94760 4/20 0.54
GSR P00390 2/20 0.52
NOS2 P35228 4/20 0.50
CYP1A2 P05177 3/20 0.50
CYP2C19 P33261 2/20 0.50
TSHR P16473 2/20 0.50
GLA P06280 1/20 0.50
NFKB1 P19838 1/20 0.50
APEX1 P27695 1/20 0.50
KMT2A Q03164 2/20 0.48
ALOX15 P16050 1/20 0.48
BLM P54132 1/20 0.48
PMP22 Q01453 1/20 0.48
NOS1 P29475 4/20 0.47
NOS3 P29474 3/20 0.47
MEN1 O00255 1/20 0.47
ARG2 P78540 4/20 0.47
ARG1 P05089 3/20 0.47
CYP3A4 P08684 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
L-Citrulline SCHEMBL20588 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL215403 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL288641 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL20587 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL9070200 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL15909605 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL4542892 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL15909604 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL22426116 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL20742804 0.98 OTC (0.57) OTCDDAH1GSRNOS2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 582 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122070294-A Stable vitreous material based on histidine, arginine and glutamic acid amino acids 阵序补丁有限公司 2026-05-19 CN claimed
WO-2026098644-A1 TARGETED PROTEIN DEGRADATION AGENT, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 北京森妙生物科技有限公司 2026-05-15 WO claimed
US-20260131015-A1 NEODEGRADER CONJUGATES ORUM THERAPEUTICS INC (KR) 2026-05-14 US claimed
US-20260097117-A1 CONJUGATES ORUM THERAPEUTICS INC (KR) 2026-04-09 US claimed
EP-4720087-A1 PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR Zealand Pharma A/S (DK) 2026-04-08 EP claimed
EP-4720086-A1 PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR Zealand Pharma A/S (DK) 2026-04-08 EP claimed
US-20260001910-A1 PEPTIDES AND USES THEREOF PREVECEUTICAL MEDICAL INC (CA) 2026-01-01 US claimed
EP-4652183-A1 PEPTIDE-DRUG CONJUGATES FOR TARGETED THERAPY OF RENAL DISEASES Shanghai MicuRx Pharmaceutical Co., Ltd. (CN) 2025-11-26 EP claimed
WO-2025228947-A1 BIFUNCTIONAL COMPOUNDS CAPABLE OF INDUCING DEGRADATION OF POLO-LIKE KINASE1 CROSSFIRE ONCOLOGY B.V. (NL) 2025-11-06 WO claimed
EP-4598587-A1 NEODEGRADER CONJUGATES Orum Therapeutics Inc. (KR) 2025-08-13 EP claimed
EP-4126068-A1 CONJUGATES Orum Therapeutics Inc. (KR) 2023-02-08 EP claimed
CN-115505171-A Novel organic zinc salt PVC compound heat stabilizer and preparation method and application thereof 浙江工业大学 2022-12-23 CN claimed
WO-2022254377-A1 NEODEGRADER-ANTI-CD33 ANTIBODY CONJUGATES ORUM THERAPEUTICS, INC. (KR) 2022-12-08 WO claimed
CN-115184478-A Quantitative analysis method of 70 amino substances in blood plasma based on 'derivatization in fiber' strategy and application thereof 沈阳药科大学 2022-10-14 CN claimed
WO-2022096387-A1 APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD AND PROCESS OF CALCULATING SET FLOW RATES IN A MEDICAL APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD GAMBRO LUNDIA AB (SE) 2022-05-12 WO claimed
CN-109196004-B Engineered scaffold for vascularized tissue repair 加利福尼亚大学董事会 2022-03-18 CN claimed
US-20140057850-A1 PEPTIDE FOR USE IN THE TREATMENT OF SKIN CONDITIONS ORGANOBALANCE GMBH (DE) 2014-02-27 US claimed
EP-2673288-A1 PEPTIDE FOR USE IN THE TREATMENT OF SKIN CONDITIONS Organo Balance GmbH (DE) 2013-12-18 EP claimed
CN-103415531-A Peptide for use in the treatment of skin conditions ORGANO BALANCE GMBH 2013-11-27 CN claimed
WO-2012107244-A1 PEPTIDE FOR USE IN THE TREATMENT OF SKIN CONDITIONS ORGANOBALANCE GMBH (DE) 2012-08-16 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140057850-A1 PEPTIDE FOR USE IN THE TREATMENT OF SKIN CONDITIONS NGLY1, FPR3, CUTA OTC 2152/4885DDAH1 2635/4885GSR 4004/4885
US-20260097117-A1 CONJUGATES CRBN, CUL4B, CUL4A OTC 4457/4885DDAH1 2992/4885GSR 4768/4885
US-20260001910-A1 PEPTIDES AND USES THEREOF MMP3, PEPD, MMP9 OTC 1979/4885DDAH1 567/4885GSR 2148/4885
US-20260131015-A1 NEODEGRADER CONJUGATES FCGR2A, FCGR3B, CD47 OTC 3190/4885DDAH1 1846/4885GSR 2264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.