L-Citrulline

L-Citrulline

SCHEMBL15909605

N[C@@H](CCCN[13C](N)=O)C(=O)O

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OTC P00480 1/20 0.59
DDAH1 O94760 4/20 0.54
GSR P00390 2/20 0.52
NOS2 P35228 4/20 0.50
CYP1A2 P05177 3/20 0.50
CYP2C19 P33261 2/20 0.50
TSHR P16473 2/20 0.50
GLA P06280 1/20 0.50
NFKB1 P19838 1/20 0.50
APEX1 P27695 1/20 0.50
KMT2A Q03164 2/20 0.48
ALOX15 P16050 1/20 0.48
BLM P54132 1/20 0.48
PMP22 Q01453 1/20 0.48
NOS1 P29475 4/20 0.47
NOS3 P29474 3/20 0.47
MEN1 O00255 1/20 0.47
ARG2 P78540 4/20 0.47
ARG1 P05089 3/20 0.47
CYP3A4 P08684 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
L-Citrulline SCHEMBL20588 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL215403 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL288641 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL20587 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL9070200 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL437142 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL4542892 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL15909604 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL22426116 1.00 OTC (0.59) OTCDDAH1GSRNOS2CYP1A2
L-Citrulline SCHEMBL20742804 0.98 OTC (0.57) OTCDDAH1GSRNOS2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 284 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260098061-A1 EPHA2-BINDING PENDING PEPTIDE AND COMPOSITION COMPRISING SAME PEPTIDREAM INC (JP) 2026-04-09 US disclosed
EP-4594337-A2 RADIOPHARMACEUTICAL COMPOSITIONS TARGETING EPHRIN TYPE-A RECEPTOR 2 AND USES THEREOF Rayzebio, Inc. (US) 2025-08-06 EP disclosed
WO-2024194498-A2 CROSS REACTIVE MICROBIAL PEPTIDE CANCER VACCINE AND T CELL RECEPTORS REACTIVE THERETO Universität Zürich (CH) 2024-09-26 WO disclosed
US-12043845-B2 Methods of cell culture POLPHARMA BIOLOGICS S.A. (PL) 2024-07-23 US disclosed
US-12043845-B2 Methods of cell culture POLPHARMA BIOLOGICS S.A. (PL) 2024-07-23 US disclosed
WO-2024149616-A1 FERMENTATIVE PRODUCTION GUANIDINOACETIC ACID (GAA) FROM SERINE USING A MICROORGANISM HAVING AN ENHANCED L-SERINE HYDROXYMETHYLTRANSFERASE ACTIVITY EVONIK OPERATIONS GMBH (DE) 2024-07-18 WO disclosed
WO-2024149617-A1 FERMENTATIVE PRODUCTION GUANIDINOACETIC ACID (GAA) FROM SERINE BY ATTENUATING L SERINE AMMONIA LYASE ACTIVITY IN MICROORGANISMS EVONIK OPERATIONS GMBH (DE) 2024-07-18 WO disclosed
WO-2024151843-A1 TARGETED UNIVERSAL DELIVERY SYSTEM OF DON AND OTHER DRUGS THE JOHNS HOPKINS UNIVERSITY (US) 2024-07-18 WO disclosed
US-12036206-B2 Compositions and methods for pain relief CROSS III WILLIAM H (US) 2024-07-16 US disclosed
US-12036206-B2 Compositions and methods for pain relief CROSS III WILLIAM H (US) 2024-07-16 US disclosed
US-20080279868-A1 Antibody-Drug Conjugates and Methods of Use MEDAREX, INC. (US) 2008-11-13 US disclosed
US-20080279868-A1 Antibody-Drug Conjugates and Methods of Use MEDAREX, INC. (US) 2008-11-13 US disclosed
US-20080227152-A1 Translation systems with orthogonal aminoacyl tRNA synthetase; membrane proteins THE SCRIPPS RESEARCH INSTITUTE (US) 2008-09-18 US disclosed
WO-2008073918-A1 NON-STANDARD AMINO ACID CONJUGATES OF AMPHETAMINE AND PROCESSES FOR MAKING AND USING THE SAME KEMPHARM, INC. (US) 2008-06-19 WO disclosed
US-20080139653-A1 Non-standard amino acid conjugates of amphetamine and processes for making and using the same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-06-12 US disclosed
US-20080139653-A1 Non-standard amino acid conjugates of amphetamine and processes for making and using the same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-06-12 US disclosed
US-20070276134-A1 COMPOSITIONS AND METHODS FOR COMPLEXES OF NUCLEIC ACIDS AND ORGANIC CATIONS NASTECH PHARMACEUTICAL COMPANY INC. (US) 2007-11-29 US disclosed
US-20070276134-A1 COMPOSITIONS AND METHODS FOR COMPLEXES OF NUCLEIC ACIDS AND ORGANIC CATIONS NASTECH PHARMACEUTICAL COMPANY INC. (US) 2007-11-29 US disclosed
WO-2007062664-A2 ENZYMATIC ENCODING METHODS FOR EFFICIENT SYNTHESIS OF LARGE LIBRARIES NUEVOLUTION A/S (DK) 2007-06-07 WO disclosed
WO-2007038658-A2 ANTIBODY-DRUG CONJUGATES AND METHODS OF USE MEDAREX, INC. (US) 2007-04-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070276134-A1 COMPOSITIONS AND METHODS FOR COMPLEXES OF NUCLEIC ACIDS AND ORGANIC CATIONS NSUN2, NSUN3, POLRMT OTC 281/4885DDAH1 830/4885GSR 3021/4885
US-12036206-B2 Compositions and methods for pain relief CBS, CTH, CPT1B OTC 168/4885DDAH1 1438/4885GSR 387/4885
US-20080139653-A1 Non-standard amino acid conjugates of amphetamine and processes for making and using the same SLC6A3, AADAT, SLC6A2 OTC 337/4885DDAH1 67/4885GSR 2538/4885
US-20260098061-A1 EPHA2-BINDING PENDING PEPTIDE AND COMPOSITION COMPRISING SAME EPHA2, EPHA1, EPHB1 OTC 4846/4885DDAH1 1170/4885GSR 4580/4885
US-20080279868-A1 Antibody-Drug Conjugates and Methods of Use CD47, ANTXR2, CD2BP2 OTC 4038/4885DDAH1 2254/4885GSR 3771/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.