SCHEMBL9057052

SCHEMBL9057052

C=C1C(=O)NC(=O)C1c1cccc([N+](=O)[O-])c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1F O60840 3/20 0.46
CACNA1D Q01668 3/20 0.46
CACNA1S Q13698 3/20 0.46
CACNA1C Q13936 3/20 0.46
ADORA3 P0DMS8 1/20 0.46
KDM4E B2RXH2 3/20 0.45
LMNA P02545 4/20 0.44
TSHR P16473 2/20 0.44
KMT2A Q03164 4/20 0.44
MEN1 O00255 3/20 0.44
MAPT P10636 3/20 0.44
ALDH1A1 P00352 3/20 0.44
GAA P10253 2/20 0.44
TDP1 Q9NUW8 1/20 0.43
HIF1A Q16665 3/20 0.43
CYP1A2 P05177 2/20 0.43
CYP3A4 P08684 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2341298 0.74 MAPT (0.42) LMNAKMT2AMEN1MAPTALDH1A1
SCHEMBL26304201 0.72 TDP1 (0.56) KDM4ELMNATSHRKMT2AMEN1
SCHEMBL10718546 0.72 CACNA1F (0.62) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL3385200 0.71 KDM4E (0.53) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL2346396 0.71 KMT2A (0.46) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL9689742 0.71 CACNA1F (0.61) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL10840857 0.70 TSHR (0.59) KDM4ELMNATSHRKMT2AMEN1
SCHEMBL10863772 0.70 LMNA (0.65) KDM4ELMNATSHRKMT2AMEN1
SCHEMBL6928301 0.69 ABCC9 (0.50) CACNA1FCACNA1DCACNA1SCACNA1CADORA3
SCHEMBL2346045 0.69 CACNA1F (0.38) CACNA1FCACNA1DCACNA1SCACNA1CADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996015107-A1 DITHIOCARBAMATE DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1996-05-23 WO disclosed