Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.49 |
| ▸ | PTAFR | P25105 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KCNA1 | Q09470 | 2/20 | 0.45 |
| ▸ | KCNAB1 | Q14722 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7992940 | 0.90 | NOTUM (0.65) | NOTUMBAZ2BRAB9ANPC1ALDH1A1 | |
| SCHEMBL12287671 | 0.90 | NOTUM (0.65) | NOTUMHRH3BAZ2BRAB9ANPC1 | |
| SCHEMBL7275642 | 0.82 | ESR2 (0.56) | NOTUMPTAFRHRH3 | |
| SCHEMBL6952918 | 0.81 | NOTUM (0.59) | NOTUMMCHR1PTAFRHRH3BAZ2B | |
| SCHEMBL2310027 | 0.81 | NR1H2 (0.57) | NOTUMMCHR1PTAFRHRH3BAZ2B | |
| SCHEMBL29295623 | 0.81 | NOTUM (0.53) | NOTUMPTAFRHRH3BAZ2BRAB9A | |
| SCHEMBL3440214 | 0.81 | RAB9A (0.53) | NOTUMMCHR1HRH3RAB9ANPC1 | |
| SCHEMBL11068898 | 0.81 | NOTUM (0.59) | NOTUMMCHR1PTAFRALDH1A1 | |
| SCHEMBL12013933 | 0.80 | NOTUM (0.53) | NOTUMMCHR1HRH3BAZ2BRAB9A | |
| SCHEMBL3440261 | 0.79 | ALDH1A1 (0.61) | NOTUMMCHR1HRH3ALDH1A1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996004271-A1 | CONDENSED AZEPINE DERIVATIVES, DRUGS CONTAINING THESE COMPOUNDS AND METHODS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-02-15 | — | — | WO | disclosed |
| EP-0229510-B1 | SULFINYL AND SULFONYL SUBSTITUTED-3-BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-06-06 | — | — | EP | disclosed |
| US-4824839-A | Sulfinyl and sulfonyl substituted 2,3,4,5 tetrahydro-1H-3-benzazepines and their use in treating gastrointestinal motility disorders | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-25 | — | — | US | disclosed |
| EP-0229510-A1 | Sulfinyl and sulfonyl substituted-3-benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 1987-07-22 | — | — | EP | disclosed |