Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.44 |
| ▸ | CA1 | P00915 | 7/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA4 | P22748 | 2/20 | 0.34 |
| ▸ | CA5A | P35218 | 2/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057297 | 0.78 | MAPT (0.40) | CA2CA1CA9CA12 | |
| SCHEMBL8950515 | 0.74 | CA2 (0.46) | CA2CA1CA9CA12CA4 | |
| SCHEMBL9058849 | 0.71 | CA2 (0.39) | CA2CA1CA9CA12CA4 | |
| SCHEMBL9057323 | 0.69 | CA2 (0.43) | CA2CA1CA9CA12CA4 | |
| SCHEMBL9058842 | 0.66 | CA2 (0.47) | CA2CA4 | |
| SCHEMBL9058428 | 0.66 | CA2 (0.34) | CA2CA1CA9CA12CA4 | |
| SCHEMBL9057333 | 0.65 | CA2 (0.47) | CA2CA1CA9CA12CA4 | |
| SCHEMBL9828441 | 0.63 | CA2 (0.50) | CA2CA1CA9CA12PTGS2 | |
| SCHEMBL2089350 | 0.62 | CA2 (1.00) | CA2 | |
| SCHEMBL2087596 | 0.62 | CA2 (1.00) | CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022099-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1996-07-25 | — | — | WO | disclosed |
| WO-1995019981-A1 | THIENOTHIAZINE SULFONAMIDE DERIVATIVES PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS CARBONIC ANHYDRASE INHIBITORS | ALCON LABORATORIES, INC. (US) | 1995-07-27 | — | — | WO | disclosed |