Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 14/20 | 0.50 |
| ▸ | CA1 | P00915 | 4/20 | 0.45 |
| ▸ | CA9 | Q16790 | 4/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | PTGIR | P43119 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829393 | 0.82 | CA2 (0.44) | CA2CA1CA9CA12DHFR | |
| SCHEMBL11125385 | 0.75 | CA2 (0.45) | CA2CA1CA9CA12 | |
| SCHEMBL9827840 | 0.74 | CA2 (0.58) | CA2CA1CA9CA12PTGS2 | |
| SCHEMBL958207 | 0.70 | CA2 (0.46) | CA2CA1CA9CA12 | |
| SCHEMBL9424674 | 0.69 | CA2 (0.42) | CA2 | |
| SCHEMBL9828861 | 0.67 | FBP1 (0.45) | CA2CA1CA9CA12DHFR | |
| SCHEMBL2087596 | 0.67 | CA2 (1.00) | CA2 | |
| SCHEMBL2089350 | 0.67 | CA2 (1.00) | CA2 | |
| SCHEMBL5808577 | 0.66 | GUSB (0.44) | CA2CA1CA9CA12 | |
| SCHEMBL8105269 | 0.66 | PTGS2 (0.48) | CA2CA1CA9CA12PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295049-B1 | THIOPHENE SULFONAMIDE ANTIGLAUCOMA AGENTS | MERCK & CO. INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4847289-A | Thiophene sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0295049-A2 | Thiophene sulfonamide antiglaucoma agents | MERCK & CO. INC. (US) | 1988-12-14 | — | — | EP | disclosed |