Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | RPLP1 | P05386 | 2/20 | 0.42 |
| ▸ | RPLP0 | P05388 | 2/20 | 0.42 |
| ▸ | RPS17 | P08708 | 2/20 | 0.42 |
| ▸ | RPSA | P08865 | 2/20 | 0.42 |
| ▸ | RPS2 | P15880 | 2/20 | 0.42 |
| ▸ | RPL35A | P18077 | 2/20 | 0.42 |
| ▸ | RPL7 | P18124 | 2/20 | 0.42 |
| ▸ | RPL17 | P18621 | 2/20 | 0.42 |
| ▸ | RPS4Y1 | P22090 | 2/20 | 0.42 |
| ▸ | RPS3 | P23396 | 2/20 | 0.42 |
| ▸ | RPS12 | P25398 | 2/20 | 0.42 |
| ▸ | RPL13 | P26373 | 2/20 | 0.42 |
| ▸ | RPL10 | P27635 | 2/20 | 0.42 |
| ▸ | RPL12 | P30050 | 2/20 | 0.42 |
| ▸ | RPL9; RPL9P7; RPL9P8; RPL9P9 | P32969 | 2/20 | 0.42 |
| ▸ | RPL22 | P35268 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8481469 | 0.73 | ALDH1A1 (0.48) | ALDH1A1KMT2ATSHRKDM4ESMN1; SMN2 | |
| SCHEMBL4384079 | 0.72 | ALDH1A1 (1.00) | ALDH1A1KMT2ATSHRKDM4EGAA | |
| Hydrochloric Acid SCHEMBL27486050 | 0.72 | HRH3 (0.32) | KCNH2HRH3SIGMAR1 | |
| SCHEMBL8479879 | 0.72 | ALDH1A1 (0.48) | ALDH1A1KMT2ATSHRKDM4ESMN1; SMN2 | |
| SCHEMBL4383272 | 0.70 | ALDH1A1 (0.98) | ALDH1A1KMT2ATSHRKDM4EGAA | |
| Hydrochloric Acid SCHEMBL8484742 | 0.69 | ALDH1A1 (0.48) | ALDH1A1KMT2ATSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL4912849 | 0.68 | ALOX5 (0.52) | ALDH1A1TRPM8RPLP1RPLP0RPS17 | |
| Hydrochloric Acid SCHEMBL4379167 | 0.68 | ALDH1A1 (0.83) | ALDH1A1KMT2ATSHRKDM4EGAA | |
| SCHEMBL4379159 | 0.68 | ALDH1A1 (0.87) | ALDH1A1KMT2ATSHRKDM4EGAA | |
| Hydrochloric Acid SCHEMBL8482208 | 0.67 | MBTPS1 (0.43) | KMT2AKDM4ESIGMAR1CCR3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996020173-A1 | PIPERAZINE DERIVATIVES, MEDICAMENTS CONTAINING THE SAME, THEIR USE AND PROCESS FOR PREPARING THE SAME | DR. KARL THOMAE GMBH (DE) | 1996-07-04 | — | — | WO | disclosed |