Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9059864 | 0.86 | SIGMAR1 (0.40) | SIGMAR1L3MBTL1CYP2C9 | |
| SCHEMBL9059169 | 0.85 | POLB (0.39) | SIGMAR1POLBL3MBTL1KMT2AKDM4E | |
| SCHEMBL9061357 | 0.85 | SIGMAR1 (0.60) | SIGMAR1POLBKMT2AMAPTKDM4E | |
| SCHEMBL9059998 | 0.85 | SMN1; SMN2 (0.48) | SIGMAR1KMT2AKDM4E | |
| SCHEMBL9059304 | 0.85 | NCOA3 (0.50) | SIGMAR1POLBKMT2AKDM4E | |
| SCHEMBL9059945 | 0.84 | POLB (0.38) | SIGMAR1POLBL3MBTL1MAPTCYP2C9 | |
| SCHEMBL9059335 | 0.84 | MET (0.39) | SIGMAR1POLBL3MBTL1MAPTKDM4E | |
| SCHEMBL9059413 | 0.83 | SIGMAR1 (0.42) | SIGMAR1L3MBTL1KMT2A | |
| SCHEMBL9059944 | 0.83 | SIGMAR1 (0.48) | SIGMAR1KMT2AKDM4E | |
| SCHEMBL9311235 | 0.82 | SIGMAR1 (0.46) | SIGMAR1KMT2AMAPTCYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996017612-A1 | USE OF SUBSTITUTED PHENYLAMIDINE AND PHENYLGUANIDINE COMPOUNDS FOR THE TREATMENT OF CEREBRAL AND CARDIAC ISCHAEMIA, CONVULSION AND SICKLE CELL ANAEMIA | KNOLL AKTIENGESELLSCHAFT (DE) | 1996-06-13 | — | — | WO | disclosed |
| EP-0536151-B1 | ORTHOSUBSTITUTED BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | BOOTS CO PLC (GB) | 1994-09-14 | — | — | EP | disclosed |
| US-5302720-A | Biphenyl-substituted guanidine derivatives useful as hypoglycaemic agents | THE BOOTS COMPANY (GB) | 1994-04-12 | — | — | US | disclosed |
| WO-1992000273-A1 | ORTHOSUBSTITUTED BIPHENYL AMIDINE AND BIPHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | THE BOOTS COMPANY PLC (GB) | 1992-01-09 | — | — | WO | disclosed |