Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ADH1C | P00326 | 1/20 | 0.33 |
| ▸ | ADH1A | P07327 | 1/20 | 0.33 |
| ▸ | ADH4 | P08319 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2211195 | 1.00 | CYP1A2 (0.41) | CYP1A2PKMMEN1KMT2AHTT | |
| SCHEMBL8754355 | 1.00 | CYP1A2 (0.41) | CYP1A2PKMMEN1KMT2AHTT | |
| SCHEMBL1249367 | 0.94 | CYP1A2 (0.47) | CYP1A2PKMMEN1KMT2AHTT | |
| SCHEMBL2210902 | 0.94 | CYP1A2 (0.45) | CYP1A2PKMMEN1KMT2AHTT | |
| SCHEMBL10833224 | 0.94 | CYP1A2 (0.45) | CYP1A2PKMMEN1KMT2AHTT | |
| SCHEMBL8753758 | 0.88 | CYP1A2 (0.52) | CYP1A2PKMMEN1KMT2AHTT | |
| SCHEMBL1509950 | 0.86 | TLR4 (0.38) | CYP1A2CYP2C9LMNAMAPT | |
| SCHEMBL9625923 | 0.86 | TLR4 (0.38) | CYP1A2CYP2C9LMNAMAPT | |
| SCHEMBL9625925 | 0.86 | TLR4 (0.38) | CYP1A2CYP2C9LMNAMAPT | |
| SCHEMBL8755857 | 0.86 | CYP1A2 (0.50) | CYP1A2PKMMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536442-A | ELECTROOPTICS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-16 | — | — | US | disclosed |
| EP-0381728-B1 | DIFLUOROMETHYL COMPOUNDS | MERCK PATENT GMBH (DE) | 1993-12-08 | — | — | EP | disclosed |
| EP-0381728-A1 | DIFLUOROMETHYL COMPOUNDS. | MERCK PATENT GMBH (DE) | 1990-08-16 | — | — | EP | disclosed |
| WO-1990001056-A1 | DIFLUOROMETHYL COMPOUNDS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1990-02-08 | — | — | WO | disclosed |
| EP-0182054-A2 | Heterocyclic compounds | MERCK PATENT GmbH (DE) | 1986-05-28 | — | — | EP | disclosed |