Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.31 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.31 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9061385 | 0.98 | NOS1 (0.37) | NOS1NOS2GABRA1GABRR1GABRA5 | |
| SCHEMBL9062170 | 0.87 | NOS1 (0.37) | NOS1NOS2GABRA1GABRR1GABRA5 | |
| SCHEMBL9059941 | 0.71 | GABRA1 (0.41) | NOS1NOS2GABRA1GABRR1GABRA5 | |
| Fumaric Acid SCHEMBL9062180 | 0.69 | HCAR2 (0.46) | — | |
| Fumaric Acid SCHEMBL9062168 | 0.67 | GABRA1 (0.34) | GABRA1GABRR1GABRA5GABRB2GABRA4 | |
| SCHEMBL27459175 | 0.67 | NOS1 (0.69) | NOS1NOS2GABRA1GABRR1GABRA5 | |
| SCHEMBL27546369 | 0.67 | NOS1 (0.69) | NOS1NOS2GABRA1GABRR1GABRA5 | |
| SCHEMBL27437739 | 0.67 | NOS1 (0.69) | NOS1NOS2GABRA1GABRR1GABRA5 | |
| Bromide SCHEMBL27435910 | 0.66 | NOS1 (0.67) | NOS1NOS2GABRA1GABRR1GABRA5 | |
| Bromide SCHEMBL27435911 | 0.66 | NOS1 (0.67) | NOS1NOS2GABRA1GABRR1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717040-A1 | Thiazine or thiazepine derivatives which inhibit NOS | Japan Tobacco Inc. (JP) | 1996-06-19 | — | — | EP | claimed |
| CN-1124734-A | Thiazine- or thiazepine-derivatives | JAPAN TOBACCO INC (JP) | 1996-06-19 | — | — | CN | claimed |
| EP-0717040-A1 | Thiazine or thiazepine derivatives which inhibit NOS | Japan Tobacco Inc. (JP) | 1996-06-19 | — | — | EP | disclosed |
| CN-1124734-A | Thiazine- or thiazepine-derivatives | JAPAN TOBACCO INC (JP) | 1996-06-19 | — | — | CN | disclosed |